MR-L2 |
| Katalog-Nr.GC36653 |
MR-L2 ist ein reversibler und nicht kompetitiver allosterischer Aktivator der Long-Isoform-Phosphodiesterase-4 (PDE4), der reprÄsentative PDE4-Long-Isoform-Varianten (PDE4A4, PDE4B1, PDE4C3, PDE4D5) aktiviert.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2374703-19-0
Sample solution is provided at 25 µL, 10mM.
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MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 µM[1]. PDE4[1]
[1]. Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.
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