RO5256390 |
| Katalog-Nr.GC37548 |
RO5256390 ist ein Agonist des Spurenamin-assoziierten Rezeptors 1 (TAAR1), eines hochkonservierten G-Protein-gekoppelten Rezeptors (GPCR), der von endogenen Spurenaminen gebunden wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1043495-96-0
Sample solution is provided at 25 µL, 10mM.
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RO5256390 is an agonist of trace amine-associated receptor 1 (TAAR1), a highly conserved G-protein-coupled receptor (GPCR) bound by endogenous trace amines.RO5256390 can be used to reduce multiple behavioral effects of drugs of abuse through their actions on the mesocorticolimbic system[1].RO5256390 is a modulator of monoaminergic neurotransmission, blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties[2].
[1]. Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470. [2]. Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18(5):543-56.
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