Secretin (28-54), human |
| Katalog-Nr.GC37619 |
Secretin (28-54), human, ist ein C-terminal amidiertes Peptid mit 27 AminosÄureresten, das auf humane Sekretinrezeptoren einwirkt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108153-74-8
Sample solution is provided at 25 µL, 10mM.
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Secretin (28-54), human is a 27-amino acid residue C-terminally amidated peptide, which acts on secretin receptors. Human secretin receptor[1]
Secretin (28-54), human (Human secretin) binds to secretin receptors on the presynaptic membrane or on the Purkinje cell membrane[1]. Secretin (28-54), human (Human secretin) enhances the secretion of bicarbonate, enzymes, and K+ from the pancreas.Secretin (28-54), human is expressed in the hypothalamus and pituitary gland, and Secretin (28-54), human inhibits adrenocorticotropic hormone (ACTH) release.Secretin (28-54), human selectively depresses the glucocorticoid response to ACTH of dispersed zona fasciculata-reticularis (ZF/R) cells[2]. Secretin (28-54), human (Human secretin) is a 27-amino acid peptide and is the active form of pro-secretin, which is known as a preprohormone and is synthesized as a larger precursor like other regulatory peptides. Secretin is secreted by S cells in the small intestine and affects the function of a number of organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. Secretin is a member of the secretin-glucagon family and is secreted by S cells of the duodenum in the crypts of LieberkÜhn. Secretin affects the function of a number of organ systems and cell types. Secretin exerts its biological effects through G-protein coupled secretin receptors (SR), which are expressed in the basolateral domain of several cells. In addition to regulating the pH of the duodenal content by the control of gastric acid secretion, secretin regulates the secretion of bicarbonate ions into the duodenum from the epithelia lining the pancreatic and biliary ducts[3].
[1]. Ng SS, et al. Secretin as a neuropeptide. Mol Neurobiol. 2002 Aug;26(1):97-107. [2]. Nussdorfer GG, et al. Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis. Peptides. 2000 Feb;21(2):309-24. [3]. Afroze S, et al. The physiological roles of secretin and its receptor. Ann Transl Med. 2013 Oct;1(3):29.
| Cas No. | 108153-74-8 | SDF | |
| Formula | C130H220N44O40 | M.Wt | 3039.46 |
| Löslichkeit | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.329 mL | 1.645 mL | 3.2901 mL |
| 5 mM | 0.0658 mL | 0.329 mL | 0.658 mL |
| 10 mM | 0.0329 mL | 0.1645 mL | 0.329 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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