UNC2541 |
| Katalog-Nr.GC37858 |
UNC2541 ist ein potenter und Mer-Tyrosinkinase (MerTK)-spezifischer Inhibitor, bindet in der ATP-Tasche von MerTK, mit einem IC50 von 4,4 nM, selektiver gegenÜber Axl, Tyro3 und Flt3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1612782-86-1
Sample solution is provided at 25 µL, 10mM.
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UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1]. UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl (IC50, 120 nM), Tyro3 (IC50, 220 nM) and Flt3 (IC50, 320 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].
[1]. McIver AL, et al. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem. 2017 Feb 3;12(3):207-213.
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