VU6005806 (Synonyms: AZN-00016130) |
Katalog-Nr.GC37932 |
VU6005806 (AZN-00016130) ist ein potenter positiver allosterischer Modulator (PAM) des muskarnischen Acetylcholinrezeptors Subtyp 4 (M4) mit EC50-Werten von 94 nM, 28 nM, 87 nM und 68 nM fÜr M4 von Mensch, Ratte, Hund und Cyno.
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Cas No.: 2180914-37-6
Sample solution is provided at 25 µL, 10mM.
VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1]. IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]
[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.
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