GSK2983559 free acid |
| Katalog-Nr.GC38037 |
Die freie SÄure GSK2983559 (Verbindung 3) ist ein oral aktiver und potenter Rezeptor-interagierender Protein 2 (RIP2)-Kinase-Inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1579965-12-0
Sample solution is provided at 25 µL, 10mM.
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GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].
[1]. Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25;62(14):6482-6494.
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