Histone H3K79Me1 (69-89) amide (human, mouse, rat, bovine) (trifluoroacetate salt) (Synonyms: Histone H3 (69-89) (Lys79me1) amide, Lys(Me1)79-Histone H3 (69-89) amide, RLVREIAQDF-K(Me1)-TDLRFQSSAV-NH2) |
| Katalog-Nr.GC45481 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Histone H3K79Me1 (69-89) amide is a peptide fragment of histone H3 that corresponds to amino acid residues 70-90 of the human histone H3.1 and H3.2 sequences. Methylation of lysine 79 on histone H3 is associated with active chromatin and the silencing of telomere-associated genes by silent information regulator (Sir) proteins.1 The conversion of H3K79Me1 to H3K79Me2/3 is associated with increased expression of mixed lineage leukemia (MLL) target genes, including Hoxa9.2
References
1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).
2. Deshpande, A.J., Deshpande, A., Sinha, A.U., et al. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell 26(6), 896-908 (2014).
| Cas No. | SDF | ||
| Überlieferungen | Histone H3 (69-89) (Lys79me1) amide, Lys(Me1)79-Histone H3 (69-89) amide, RLVREIAQDF-K(Me1)-TDLRFQSSAV-NH2 | ||
| Canonical SMILES | OC(C(CO)=C(C=N1)CO)=C1C([2H])([2H])[2H].Cl | ||
| Formula | C110H182N34O32.XCF3COOH | M.Wt | 2492.9 |
| Löslichkeit | Formic Acid: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.4011 mL | 2.0057 mL | 4.0114 mL |
| 5 mM | 0.0802 mL | 0.4011 mL | 0.8023 mL |
| 10 mM | 0.0401 mL | 0.2006 mL | 0.4011 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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