DHODH-IN-13 (Synonyms: DHODH-IN-13) |
| Katalog-Nr.GF14658 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1364791-86-5
Sample solution is provided at 25 µL, 10mM.
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DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds[1].
[1]. Lolli ML, et al. New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. Eur J Med Chem. 2012 Mar;49:102-9.
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