Glaucine (Synonyms: Boldine Dimethyl Ether, (+)-Glaucine, NSC 34396, 1,2,9,10-Tetramethoxyaporphine) |
| Katalog-Nr.GC41486 |
Glaucin (O,O-Dimethylisoboldin) ist ein aus Glaucium flavum Crantz isoliertes Alkaloid mit hustenstillenden, bronchodilatatorischen und entzÜndungshemmenden Eigenschaften.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 475-81-0
Sample solution is provided at 25 µL, 10mM.
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Glaucine is an alkaloid originally isolated from G. flavum that demonstrates antitussive properties. It is structurally related to papaverine , a non-selective phosphodiesterase (PDE) inhibitor. Glaucine selectively inhibits PDE4 (Kis = 3.4 µM in human bronchus and polymorphonuclear leukocytes). It has been shown to have bronchodilation and anti-inflammatory effects, inhibiting the spontaneous and histamine-induced tone in human isolated bronchus and augmenting cyclic AMP accumulation. Glaucine also binds to the benzothiazepine site on L-type Ca2+-channels in smooth muscle, blocking calcium ion signaling. This compound has been detected as a recreational drug capable of eliciting dissociative effects.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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