GLPG2534 |
| Katalog-Nr.GC71226 |
GLPG2534 ist ein oral aktiver und selektiver IRAK4-Inhibitor mit IC50-Werten von 6,4 nM und 3,5 nM für Mensch und Maus IRAK4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095615-97-5
Sample solution is provided at 25 µL, 10mM.
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GLPG2534 (2 h) inhibits IRAK4 with IC50 values of 6.4 nM and 3.5 nM for human and mouse IRAK4[1].
GLPG2534 inhibits IL-1β–driven IL-6 release, with an IC50 of 55 nM[1].
GLPG2534 inhibits TNF-α–driven IL-6 release with an IC50 of 6.6 μM[1].
GLPG2534 (0.1-10 μM, 16 h) inhibits expression of S100A7, DEFB4A, CXCL8, TNF in Flagellin-stimulated keratinocytes[1].
GLPG2534 (0.3-10 mg/kg, p.o.) Inhibits CL097-driven release of TNF-α in blood of mice[1].
GLPG2534 (10 and 30 mg/kg, p.o., b.i.d. 5 days) attenuates inflammation in psoriasis-like mouse models[1].
GLPG2534 (3-30 mg/kg, p.o., b.i.d. 5 days) attenuates the development of IL-33- and MC903-induced AD-like skin inflammation in mice[1].
References:
[1]. Lavazais S, et al. IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases. Sci Transl Med. 2023 Feb 15;15(683):eabj3289.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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