GPX4 Inhibitor 26a (Synonyms: Glutathione Peroxidase 4 Inhibitor 26a) |
| Katalog-Nr.GC49697 |
A GPX4 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2761004-85-5
Sample solution is provided at 25 µL, 10mM.
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GPX4 inhibitor 26a is an inhibitor of glutathione peroxidase 4 (GPX4).1 It inhibits GPX4 activity by 71.7% at 1 µM. GPX4 inhibitor 26a is cytotoxic to 4T1 and MCF-7 breast cancer cells and HT-1080 fibrosarcoma cells (IC50s = 0.78, 6.9, and 0.15 µM, respectively). It decreases intracellular glutathione (GSH) levels and induces lipid peroxidation and ferroptosis in 4T1 cells when used at a concentration of 5 µM. GPX4 inhibitor 26a (15 and 30 mg/kg) reduces tumor growth in a 4T1 mouse xenograft model.
1.Tiedt, R., Degenkolbe, E., Furet, P., et al.A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patientsCancer Res.71(15)5255-5264(2011)
| Cas No. | 2761004-85-5 | SDF | |
| Überlieferungen | Glutathione Peroxidase 4 Inhibitor 26a | ||
| Canonical SMILES | ClCC(N(C(C1=CSC2=CC=CC=C21)C(NCCC3=CC=CC=C3)=O)C4=CC=C(C5=CN=CO5)C=C4)=O | ||
| Formula | C29H24ClN3O3S | M.Wt | 530 |
| Löslichkeit | Chloroform: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.8868 mL | 9.434 mL | 18.8679 mL |
| 5 mM | 0.3774 mL | 1.8868 mL | 3.7736 mL |
| 10 mM | 0.1887 mL | 0.9434 mL | 1.8868 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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