GRP-60367 hydrochloride |
Katalog-Nr.GC60885 |
GRP-60367-Hydrochlorid ist ein erstklassiger niedermolekularer Tollwutvirus (RABV)-Eintrittshemmer mit nanomolarer Wirksamkeit gegen einige RABV-StÄmme.
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Cas No.: 2803211-60-9
Sample solution is provided at 25 µL, 10mM.
GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein[1].
GRP-60367 (0.1 nM-1000 μM) confirms specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines[1]. Cell Viability Assay[1] Cell Line: BEAS-2B, 293T, or Hep-2 cell lines
[1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.
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