Indacrinone (MK196) |
| Katalog-Nr.GC31582 |
Indacrinon (MK196) (MK196) ist ein in der Erprobung befindliches Diuretikum mit ausgeprÄgter saluretischer AktivitÄt bei Ratte und Hund sowie sowohl urikosurischer als auch saluretischer AktivitÄt beim Schimpansen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 56049-88-8
Sample solution is provided at 25 µL, 10mM.
Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.
As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the Indacrinone (MK-196)/1 ratio is 0.8 and 5 for the urine and feces, respectively. The urinary ratio of Indacrinone/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2)[1].
[1]. A.G. ZACCHEI, et al. THE PHYSIOLOGICAL DISPOSITION
Animal experiment: | Sixteen mice are administered Indacrinone-14C. Four mice, 2 male and 2 female, are dosed orally with 10 mg/kg of drug and four additional mice (2M, 2F) are given the drug i.v. via the tail vein. In similar fashion eight additional mice are dosed with 1 mg/kg Indacrinone-14C either orally or intravenously.The animals are housed in separate metabolism cages, 2 mice of same sex per cage.The animals are fasted overnight prior to drug administration. Urine and feces are collected for the 24-hour period post drug. Animals are allowed free access to water. Urine specimens are also obtained from mice which receive Indacrinone orally at doses of 10 and 20 mg/kg/day for 9 days. On day 9 the mice are dosed and placed in metabolism cages; two cages are used per sex per group. Urine is collected during the five-hour period post last dose. A total of nineteen mice are dosed with 10 mg/kg and 18 mice are dosed with 20 mg/kg of drug[1]. |
References: [1]. A.G. ZACCHEI, et al. THE PHYSIOLOGICAL DISPOSITION | |
| Cas No. | 56049-88-8 | SDF | |
| Canonical SMILES | O=C(O)COC1=CC2=C(C(C(C3=CC=CC=C3)(C)C2)=O)C(Cl)=C1Cl | ||
| Formula | C18H14Cl2O4 | M.Wt | 365.21 |
| Löslichkeit | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7382 mL | 13.6908 mL | 27.3815 mL |
| 5 mM | 0.5476 mL | 2.7382 mL | 5.4763 mL |
| 10 mM | 0.2738 mL | 1.3691 mL | 2.7382 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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