IRBP (1-20) (human, rat) (trifluoroacetate salt) |
| Katalog-Nr.GC90524 |
Ein Peptid-Induktor der experimentellen Autoimmun-Uveoretinitis
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20) is a dodecapeptide fragment of IRBP, also known as retinoid-binding protein 3, which is involved in pigment regeneration by transporting retinol and retinal from photoreceptor cells to the retinal pigment epithelium.1,2 IRBP1-20 has been used to induce autoimmune uveoretinitis in C57BL/6 mice, which bear the H-2b haplotype.2 IRBP1-20 (3 µM) increases the levels of IL-4, IL-5, and IL-6 secreted from primary mouse spleen lymphocytes. Immunization and rechallenge with IRBP1-20 increases ear swelling, ocular blood vessel inflammation, immune cell infiltration, and photoreceptor layer damage, as well as retinal detachment, in IFN-γ-deficient mice.
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