JNJ-1289 |
| Katalog-Nr.GC71145 |
JNJ-1289 ist ein potenter, selektiver, kompetitiver und allosterischer humaner Sperminoxidase (hSMOX)-Hemmer (IC50: 50 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 792898-18-1
Sample solution is provided at 25 µL, 10mM.
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JNJ-1289 (0.1 nM-1 μM, 0 and 2 h) inhibits hSMOX activity in a time-dependent manner[1].
JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex[1].
References:
[1]. Elsie Diaz, et al. B Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol. 2022 Aug 5;5(1):787.
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