JTV 519 fumarate |
| Katalog-Nr.GC50064 |
Ryanodin-Rezeptor (RyR) Inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883549-36-7
Sample solution is provided at 25 µL, 10mM.
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Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.
References:
Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373
Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112
Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID:21989257
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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