Laminaran |
| Katalog-Nr.GC39259 |
Laminaran ist ein β-1-3-Glucan und ein typischer Ligand fÜr Dectin-1 aus Eisenia Bicyclis, hat starke immunmodulierende, strahlenschÜtzende und AntikrebsaktivitÄten. Laminaran besteht aus β (1→3)-Glucan mit β (1→6)-Zweige und kann durch Enzyme wie Laminarinase (EC 3.2.1.6) katalysiert werden, die die β bricht; (1→3) Anleihen. Laminaran ist ein vielversprechendes immunstimulierendes MolekÜl zur Verwendung in der Krebsimmuntherapie.
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Cas No.: 9008-22-4
Sample solution is provided at 25 µL, 10mM.
Laminaran is a neutral water-soluble β-1-3-glucan and a typical ligand for Dectin-1 isolated from the brown alga D. dichotoma, has potent immunomodulating, radioprotective, and anticancer activities[1]. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds[2]. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy[3].
[1]. Malyarenko OS, et al. Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.Carbohydr Polym. 2019 Feb 15;206:539-547. [2]. Laminaran [3]. Song K, et al. Laminarin promotes anti-cancer immunity by the maturation of dendritic cells.Oncotarget. 2017 Jun 13;8(24):38554-38567.
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