Laninamivir |
| Katalog-Nr.GC65069 |
Laninamivir (R 125489) ist ein potenter Hemmer der Influenza-Neuraminidase (NA) mit IC50-Werten von 0,90 nM, 1,83 nM und 3,12 nM fÜr Vogel-H12N5 NA (N5), pH1N1 N1 NA (p09N1) und A/RI/5+/ 1957 H2N2 N2 (p57N2).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 203120-17-6
Sample solution is provided at 25 µL, 10mM.
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Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively[1].
Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution[1].Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir[1].
[1]. Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249.
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