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Leelamine (hydrochloride) (Synonyms: Dehydroabietylamine)

Katalog-Nr.GC18496

Leelamin (Hydrochlorid) ist ein trizyklisches Diterpenmolekül, das aus der Rinde von Kiefern extrahiert wird.

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Leelamine (hydrochloride) Chemische Struktur

Cas No.: 16496-99-4

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Sample solution is provided at 25 µL, 10mM.

Description of Leelamine (hydrochloride)

Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means “play'- It has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 uM. Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 of 9.5 uM. Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A2 activity from a variety of sources.

Chemical Properties of Leelamine (hydrochloride)

Cas No. 16496-99-4 SDF
Überlieferungen Dehydroabietylamine
Chemical Name 1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine, monohydrochloride
Canonical SMILES CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3.Cl
Formula C20H31N.HCl M.Wt 321.9
Löslichkeit DMF: 20 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:2): .15 mg/ml,Ethanol: 20 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Leelamine (hydrochloride)

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1 mg 5 mg 10 mg
1 mM 3.1066 mL 15.5328 mL 31.0655 mL
5 mM 0.6213 mL 3.1066 mL 6.2131 mL
10 mM 0.3107 mL 1.5533 mL 3.1066 mL
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In vivo Formulation Calculator (Clear solution) of Leelamine (hydrochloride)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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