Lenalidomide-OH |
| Katalog-Nr.GC60223 |
Lenalidomid-OH ist ein Analogon des Cereblon (CRBN)-Liganden Lenalidomid fÜr die E3-Ubiquitin-Ligase und wird zur Rekrutierung des CRBN-Proteins verwendet. Lenalidomid-OH kann mit dem Liganden fÜr Protein durch einen Linker verbunden werden, um PROTACs zu bilden, wie z. B. den PROTAC BTK-Abbauer SJF620.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1416990-08-3
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 [1].
Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
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