Lenalidomide-propargyl-C2-NH2 hydrochloride |
| Katalog-Nr.GC38808 |
Lenalidomid-Propargyl-C2-NH2-Hydrochlorid enthÄlt einen Cereblon (CRBN)-Liganden fÜr die E3-Ubiquitin-Ligase und einen Linker. Lenalidomid-Propargyl-C2-NH2-Hydrochlorid kann zum Design des PROTAC MD-224 verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2489242-23-9
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 [1].
[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.
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