Lipid 10 |
| Katalog-Nr.GC90981 |
Ein ionisierbares kationisches Lipid.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2430034-02-7
Sample solution is provided at 25 µL, 10mM.
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Lipid 10 is an ionizable cationic lipid (pKa = 6.2-6.5).1 Lipid nanoparticles (LNPs) containing lipid 10 and encapsulating siRNA for the gene encoding cytoskeleton-associated protein 5 (CKAP5) reduce its gene expression and protein levels in vitro and selectively reduce cell viability in a variety of genetically unstable cancer cell lines.2 Administration of LNPs containing lipid 10 and encapsulating CKAP5 siRNA reduce tumor growth and increase survival in an NCI/ADR-RES human ovarian cancer mouse xenograft model.
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