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Lometrexol

Katalog-Nr.GC18404

Lometrexol (DDATHF), ein Antipurin-Antifolat, kann die AktivitÄt der Glycinamid-Ribonukleotid-Formyltransferase (GARFT) hemmen, fÜhrt jedoch nicht zu nachweisbaren DNA-StrangbrÜchen. Lometrexol kann die De-novo-Purinsynthese weiter hemmen, was zu abnormaler Zellproliferation und Apoptose und sogar zum Stillstand des Zellzyklus fÜhrt. Lometrexol hat AntikrebsaktivitÄt. Lometrexol ist auch ein starker Hemmer der menschlichen Serin-Hydroxymethyltransferase 1/2 (hSHMT1/2).

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Lometrexol Chemische Struktur

Cas No.: 106400-81-1

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1mg
93,00 $
Auf Lager
5mg
233,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products
Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity. At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.

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Average Rating: 5 ★★★★★ (Based on Reviews and 28 reference(s) in Google Scholar.)

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