LUF5771 |
| Katalog-Nr.GC62173 |
LUF5771 ist ein potenter allosterischer rekombinanter luteinisierender Hormon (recLH) und Org 43553-Inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1141802-49-4
Sample solution is provided at 25 µL, 10mM.
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LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy[1].
LUF5771 (1 µM or 10 µM) allosteric inhibition is concentration-dependent. LUF5771 significantly increases radioligand dissociation. LUF5771 probably binds to the seven transmembrane domain like Org 43553 does. LUF5771 (10 µM) alone is able to partially activate the LH receptor by 31±4%[1].
[1]. Laura H. Heitman, et al. Substituted Terphenyl Compounds as the First Class of Low Molecular Weight Allosteric Inhibitors of the Luteinizing Hormone Receptor. Journal of Medicinal Chemistry 2009 52 (7), 2036-2042
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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