Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) (Synonyms: Lys-Nε-MCC-DM1) |
| Katalog-Nr.GC33500 |
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) (Lys-Nε-MCC-DM1) ist eine Linker-Payload-Komponente, die das Potenzial hat, die Tubulin-Polymerisation zu hemmen.Lys-SMCC-DM1 (Lys-Nε -MCC-DM1) ist der aktive Metabolit von T-DM1. T-DM1 ist ein auf den humanen epidermalen Wachstumsfaktor-Rezeptor 2 (HER2) gerichtetes ADC mit einem Tubulin-Polymerisationsinhibitor DM1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1281816-04-3
Sample solution is provided at 25 µL, 10mM.
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Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is an FDA approved HER2-targeting ADC.
[1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.
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