m-PEG12-amine |
| Katalog-Nr.GC66195 |
m-PEG12-Amin ist ein PEG-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann. m-PEG12-Amin ist auch ein nicht spaltbarer PEG-ADC-Linker mit 12 Einheiten, der bei der Synthese von AntikÖrper-Wirkstoff-Konjugaten (ADCs) verwendet wird.
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Cas No.: 1977493-48-3
Sample solution is provided at 25 µL, 10mM.
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m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
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