m-PEG5-succinimidyl carbonate |
| Katalog-Nr.GC67138 |
m-PEG5-Succinimidylcarbonat ist ein nicht spaltbarer PEG-ADC-Linker mit 5 Einheiten, der bei der Synthese von Antikörper-Wirkstoff-Konjugaten (ADCs) verwendet wird. m-PEG5-Succinimidylcarbonat ist ein PEG/Alkyl/Ether-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann.
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Cas No.: 1058691-00-1
Sample solution is provided at 25 µL, 10mM.
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m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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