Mcl1-IN-8 |
Katalog-Nr.GC38811 |
Mcl1-IN-8 (Verbindung 8) ist ein oral aktiver Mcl-1-PUMA-GrenzflÄcheninhibitor mit einem Ki von 0,3 μM. Mcl1-IN-8 zeigt eine doppelte AktivitÄt bei der Verringerung der PUMA-abhÄngigen Apoptose, wÄhrend es die Mcl-1-vermittelte Anti-Apoptose in Krebszellen deaktiviert.
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Cas No.: 678158-55-9
Sample solution is provided at 25 µL, 10mM.
Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].
[1]. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.
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