Milbemycin A4 oxime (Synonyms: 5-Ketomilbemycin A4 oxime, 5-Oxomilbemycin A4 5-oxime) |
| Katalog-Nr.GC44195 |
Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime, compounds that both have insecticidal and nematocidal activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 93074-04-5
Sample solution is provided at 25 µL, 10mM.
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Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/ml. Milbemycin A4 oxime (2.5 μg/ml) blocks efflux of fluconazole from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, and reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata. It enhances adriamycin-induced inhibition of cell growth, as well as increases the intracellular accumulation of adriamycin and the P-glycoprotein substrate rhodamine 123 , in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells in a concentration-dependent manner.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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