Mitotane (Lsodren) (Synonyms: o,p'-DDD, 1,1-Dichlorodiphenildichloroethane, NSC 38721) |
| Katalog-Nr.GC16976 |
Mitotan (Lsodren) (2,4′-DDD), ein Isomer von DDD und Derivat von Dichlordiphenyltrichlorethan (DDT), ist ein antineoplastisches Mittel und kann zur Erforschung von Nebennierenrindenkarzinomen verwendet werden. Mitotan (Lsodren) Übt seine adrenocorticolytische Wirkung zumindest teilweise durch LipotoxizitÄt aus, die durch intrazellulÄre Akkumulation von freiem Cholesterin (FC) induziert wird. Mitotan (Lsodren) kann direkte Auswirkungen auf die Hypophyse auf kortikotrophe Zellen haben. Mitotan (Lsodren) kann die CYP3A4-Genexpression Über die Aktivierung von Steroiden und xenobiotischen Rezeptoren (SXR) induzieren und weist Arzneimittelwechselwirkungen auf.
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Cas No.: 53-19-0
Sample solution is provided at 25 µL, 10mM.
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Mitotane(2,4′-DDD), an isomer of DDD and derivative of DDT, is an antineoplastic medication used in the treatment of adrenocortical carcinoma.IC50 value: Target: Mitotane alters steroid peripheral metabolism, directly suppresses the adrenal cortex and alters cortisone metabolism leading to hypocortisolism. Side effects as reported by Schteinberg et al. include anorexia and nausea (88%), diarrhea (38%), vomiting (23%), decreased memory and ability to concentrate (50%), rash (23%), gynecomastia (50%), arthralgia (19%), and leukopenia (7%).
References:
[1]. Gentilin E, Tagliati F, Terzolo M, Mitotane reduces human and mouse ACTH-secreting pituitary cell viability and function. J Endocrinol. 2013 Jul 29;218(3):275-285.
[2]. Lehmann TP, Wrzesiński T, Jagodziński PP. The effect of mitotane on viability, steroidogenesis and gene expression in NCI H295R adrenocortical cells. Mol Med Rep. 2013 Mar;7(3):893-900.
[3]. Takeshita A, Igarashi-Migitaka J, Koibuchi N, Mitotane induces CYP3A4 expression via activation of the steroid and xenobiotic receptor. J Endocrinol. 2013 Feb 15;216(3):297-305.
[4]. Ederhy S, Cohen A, Dufaitre G, No evidence for relevant QT interval prolongation in mitotane-treated patients with adrenocortical carcinoma. J Endocrinol Invest. 2012 Nov;35(10):911-4.
[5]. Alexandraki KI, Kaltsas GA, le Roux CW, Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study. Clin Endocrinol (Oxf). 2010 Mar;72(3):305-11.
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