MK2-IN-5 acetate |
| Katalog-Nr.GC72100 |
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (Ki= 8 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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MK2-IN-5 acetate (5-10 μM, 2 h) inhibits TGF-b1 induced connective tissue growth factor (CTGF) and collagen type I in primary human keloid fibroblasts[3].
MK2-IN-5 acetate (2 mg/kg Intraperitoneal injection, single dose) decreased HSP25 phosphorylation in ventilator-associated lung injury model[2].
References:
[1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480.
[2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600.
[3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539.
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