ML-179 (Synonyms: CID45100448) |
| Katalog-Nr.GC44215 |
ML-179 (SR-1309) ist ein inverser LRH1 (Leberrezeptor-Homolog-1)-Agonist mit einem IC50-Wert von 320 nM. ML-179 zeigt Antiproliferationsaktivität in MDA-MB-231-Zellen. ML-179 hat das Potenzial für die Erforschung von ER-negativem Brustkrebs.
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Cas No.: 1883548-87-5
Sample solution is provided at 25 µL, 10mM.
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ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.12 µM).
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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