Mps1-IN-1 dihydrochloride |
| Katalog-Nr.GC50110 |
Mps1-IN-1-Dihydrochlorid ist ein potenter und ATP-kompetitiver Mps1-Kinase-Inhibitor mit einem IC50 von 367 nM. Mps1-IN-1-Dihydrochlorid hemmt die AktivitÄt der mitotischen Mps1-Kinase und hebt die Funktion des Spindel-Assembly-Checkpoints (SAC) auf. Mps1-IN-1-Dihydrochlorid verringert die LebensfÄhigkeit sowohl von Krebszellen als auch von „normalen" Zellen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883548-93-3
Sample solution is provided at 25 µL, 10mM.
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Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.
Kwiatkowski et al (2010) Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 6 359 PMID:20383151 |Miduturu et al (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 18 868 PMID:21802008 |Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 190 21 PMID:20624898
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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