MreB Perturbing Compound A22 (Synonyms: A22 hydrochloride) |
| Katalog-Nr.GC44248 |
MreB Perturbing Compound A22 ist eine Benzylisothioharnstoff-Verbindung, die schnell und reversibel mit der ATP-Bindungsstelle von MreB interagiert.
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Cas No.: 22816-60-0
Sample solution is provided at 25 µL, 10mM.
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MreB is an actin-like protein expressed in bacteria. It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity. MreB perturbing compound A22 is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly. It blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml). It interferes with chromosome segregation in C. crescentus by preventing MreB binding to chromosomes. In V. cholerae, A22 prevents the development of normal cell shape and alters nucleoid morphology.
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