N-Boc-PEG9-alcohol |
Katalog-Nr.GC66730 |
N-Boc-PEG9-Alkohol ist ein PEG/Alkyl/Ether-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann. N-Boc-PEG9-Alkohol ist ein spaltbarer ADC-Linker, der bei der Synthese von Antikörper-Wirkstoff-Konjugaten (ADCs) verwendet wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2112731-44-7
Sample solution is provided at 25 µL, 10mM.
N-Boc-PEG9-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG9-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Nello Mainolfi, wt al. Irak degraders and uses thereof. US20190192668A1.
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