N-desmethyl Olanzapine (Synonyms: LY170055, 4'-N-desmethyl Olanzapine) |
| Katalog-Nr.GC48804 |
A major metabolite of olanzapine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 161696-76-0
Sample solution is provided at 25 µL, 10mM.
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N-desmethyl Olanzapine is a major metabolite of the atypical antipsychotic agent olanzapine .1,2 N-desmethyl Olanzapine is formed via oxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoform CYP1A2.1
1.Ring, B.J., Catlow, J., Lindsay, T.J., et al.Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapineJ. Pharmacol. Exp. Ther.276(2)658-666(1996) 2.Chiu, J.A., and Franklin, R.B.Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detectionJ. Pharm. Biomed. Anal.14(5)609-615(1996)
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