Neuromedin N (trifluoroacetate salt) (Synonyms: NMN) |
| Katalog-Nr.GC44376 |
Neuromedin N is a neurotensin-like hexapeptide that is synthesized from the same precursor as neurotensin.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Neuromedin N is a neurotensin-like hexapeptide that is synthesized from the same precursor as neurotensin. It is highly expressed in the brain but is also expressed in the gastrointestinal system and adrenal glands. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin (IC50s = 16.7 and 3 nM, respectively). Neuromedin N (10 pM) increases the phagocytic function of isolated murine peritoneal macrophages and increases chemotaxis two-fold compared with control, an effect that is blocked by the calcium-channel blocker ryanodine. It induces hypotension in rats and contraction of isolated guinea pig ileum. Neuromedin N (0.05 - 5 μg, i.c.v.) also elicits hypothermia in rats in a dose- and time-dependent manner, which is potentiated by bestatin . Neuromedin N is more potent than neurotensin in stimulating spontaneous motor activity and increasing dopamine metabolism in several brain regions following injection into the rat ventral tegmental area but is less potent than neurotensin when injected into the nucleus accumbens.
| Cas No. | SDF | ||
| Überlieferungen | NMN | ||
| Canonical SMILES | [H]N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O.FC(F)(C(O)=O)F | ||
| Formula | C38H63N7O8•XCF3COOH | M.Wt | 745.9 |
| Löslichkeit | Water: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3407 mL | 6.7033 mL | 13.4066 mL |
| 5 mM | 0.2681 mL | 1.3407 mL | 2.6813 mL |
| 10 mM | 0.1341 mL | 0.6703 mL | 1.3407 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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