Nicotianamine

Nicotianamine is a metal chelator and phytosiderophore precursor produced in plants that has a role in the uptake, translocation, and intracellular transport of metals. [1] Treating lettuce (L. sativa) with a Cu(OH)2-based pesticide raises nicotianamine levels 12- to 27-fold compared to non-pesticide treated plants. [2] Nicotianamine also inhibits rabbit angiotensin-coverting enzyme (ACE) (IC50 = 0.26 μM) and human recombinant ACE2 (IC50 = 84 nM). [3] [4]

Reference:
[1]. Curie, C., Cassin, G., Couch, D., et al. Metal movement within the plant: Contribution of nicotianamine and yellow stripe 1-like transporters. Ann. Bot. 103(1), 1-11 (2009).
[2]. Zhao, L., Ortiz, C., Adeleye, A.S., et al. Metabolomics to detect response of lettuce (Lactuca sativa) to Cu(OH)2 nanopesticides: Oxidative stress response and detoxification mechanisms. Environ. Sci. Technol. 50(17), 9697-9707 (2016).
[3]. Kinoshita, E., J., Y., and Kikuchi, M. Purification and identification of an angiotensin I-converting enzyme inhibitor from soy sauce. Biosci. Biotech. Biochem. 57(7), 1107-1110 (1993).
[4]. Takahashi, S., Yoshiya, T., Yoshizawa-Kumagaye, K., et al. Nicotianamine is a novel angiotensin-converting enzyme 2 inhibitor in soy-bean. Biomed. Res. (Tokyo) 36(3), 219-224 (2015).