Nitroflurbiprofen (HCT 1206) |
| Katalog-Nr.GC34028 |
Nitroflurbiprofen (HCT 1206) ist ein Cyclooxygenase (COX)-Hemmer mit Stickoxid (NO)-spendenden Eigenschaften, der den erhÖhten intrahepatischen GefÄßtonus bei Ratten mit portaler Hypertonie und Zirrhose moduliert.
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Cas No.: 158836-71-6
Sample solution is provided at 25 µL, 10mM.
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Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1].
[1]. Laleman W, et al. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portalhypertension in rats. Gastroenterology. 2007 Feb;132(2):709-19.
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