Noscapine-13C-d3 (Synonyms: Narcotine-13C-d3, Opianine-13C-d3)

Noscapine-¹³C-d₃ is intended for use as an internal standard for the quantification of noscapine by GC- or LC-MS. Noscapine is an alkaloid that has been found in opium and has anticancer and antitussive properties.^1,2,3 It binds to tubulin and induces cell cycle arrest at the G₂/M phase in HeLa cells when used at a concentration of 20 µM.² Noscapine induces apoptosis in HeLa cells and thymocytes (IC₅₀s = 25 and 10 µM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC₅₀s = 42.3 and 39.1 µM, respectively). In vivo, noscapine (120 mg/kg) induces tumor regression in an MCF-7 mouse xenograft model. Noscapine (30 and 70 mg/kg) decreases the number of citric acid-induced coughs in guinea pigs.³

1.Kingston, D.G.I.Tubulin-interactive natural products as anticancer agentsJ. Nat. Prod.72(3)507-515(2009) 2.Ye, K., Ke, Y., Keshava, N., et al.Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cellsProc. Nat. Acad. Sci. U.S.A.95(4)1601-1606(1998) 3.Idaan-Heikkila, J.E., Jalonen, K., and Vartiainen, A.Evaluation of the antitussive effect of noscapine and codeine on citric acid cough in guinea-pigsActa. Pharmacol. Toxicol. (Copenh)25(3)333-338(1967)