NSC 636819 |
| Katalog-Nr.GC50136 |
NSC 636819 ist ein kompetitiver und selektiver Inhibitor von KDM4A/KDM4B. KDM4A/KDM4B sind potenzielle Progressionsfaktoren für Prostatakrebs. NSC 636819 hat das Potenzial für die Erforschung von Krebserkrankungen, insbesondere Prostatakrebs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1618672-71-1
Sample solution is provided at 25 µL, 10mM.
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KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID:24971742
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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