P110 (trifluoroacetate salt) |
| Katalog-Nr.GC90607 |
Ein Peptid-Inhibitor von DRP1
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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P110 is a peptide inhibitor of the mitochondrial GTPase dynamin-related protein 1 (DRP1).1 It selectively inhibits DRP1 GTPase activity over the additional mitochondrial GTPases OPA1, MFN1, and dynamin 1 at 1 µM. P110 (1 µM) inhibits the MPP+-induced protein-protein interaction between DRP1 and mitochondrial fission 1 (FIS1), as well as MPP+-, carbonyl cyanide M-chloro phenyl drazone-, rotenone-, or drogen peroxide-induced DRP1 translocation to the mitochondria in SH-SY5Y cells. It also inhibits MPP+-induced mitochondrial apoptosis and autophagy in SH-SY5Y cells and MPP+-induced mitochondrial fragmentation and cell death in a primary rat dopaminergic neuronal model of Parkinson’s disease.
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