Palmitoyl Ethanolamide-d4 (Synonyms: Palmidrold4, PEAhydroxyethyl1,1,2,2d4)

Palmitoyl ethanolamide-d₄ (PEA-d₄) contains four deuterium atoms at the 1,1', 2, and 2' positions. It is intended for use as an internal standard for the quantification of PEA by GC- or LC-mass spectrometry. Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.¹ PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.² PEA is an endocannabinoid which has been shown to significantly elevate cAMP in cells expressing CB₂ receptors. However, its affinity for CB₂ receptors is relatively low, at about 10 µM. CB₁ receptors have no appreciable affinity for PEA.³

1.Bachur, N.R., Masek, K., Melmon, K.L., et al.Fatty acid amides of ethanolamine in mammalian tissuesJ. Biol. Chem.2401019-1024(1965) 2.Ganley, O.H., Graessle, O.E., Robinson, H.J., et al.Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithinJournal of Laboratory and Clinical Medicine51709-714(1958) 3.Devane, W.A., Hanus, L., Breuer, A., et al.Isolation and structure of a brain constituent that binds to the cannabinoid receptorScience258(5090)1946-1949(1992)