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Palmitoyl Ethanolamide-d5 (Synonyms: Palmidrold5, PEA15,15,16,16,16d5)

Katalog-Nr.GC47866

A neuropeptide with diverse biological activities

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Palmitoyl Ethanolamide-d5 Chemische Struktur

Cas No.: N/A

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100 μg
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Sample solution is provided at 25 µL, 10mM.

Description of Palmitoyl Ethanolamide-d5

Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.1 PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.2 PEA is an endocannabinoid which has been shown to significantly elevate cAMP in cells expressing CB2 receptors. However, its affinity for CB2 receptors is relatively low, at about 10 µM. CB1 receptors have no appreciable affinity for PEA.3

1.Bachur, N.R., Masek, K., Melmon, K.L., et al.Fatty acid amides of ethanolamine in mammalian tissuesJ. Biol. Chem.2401019-1024(1965) 2.Ganley, O.H., Graessle, O.E., Robinson, H.J., et al.Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithinJournal of Laboratory and Clinical Medicine51709-714(1958) 3.Devane, W.A., Hanus, L., Breuer, A., et al.Isolation and structure of a brain constituent that binds to the cannabinoid receptorScience258(5090)1946-1949(1992)

Chemical Properties of Palmitoyl Ethanolamide-d5

Cas No. N/A SDF
Überlieferungen Palmidrold5, PEA15,15,16,16,16d5
Canonical SMILES O=C(NCCO)CCCCCCCCCCCCCC([2H])([2H])C([2H])([2H])[2H]
Formula C18H32D5NO2 M.Wt 304.5
Löslichkeit DMF: 2 mg/ml,Ethanol: 5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Palmitoyl Ethanolamide-d5

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.2841 mL 16.4204 mL 32.8407 mL
5 mM 0.6568 mL 3.2841 mL 6.5681 mL
10 mM 0.3284 mL 1.642 mL 3.2841 mL
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In vivo Formulation Calculator (Clear solution) of Palmitoyl Ethanolamide-d5

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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