Pamoic Acid (Synonyms: Embonic Acid, NSC 30188, NSC 40132) |
| Katalog-Nr.GC44553 |
PamoinsÄure ist ein potenter GPR35-Agonist mit einem EC50 von 79 nM.
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Cas No.: 130-85-8
Sample solution is provided at 25 µL, 10mM.
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Pamoic acid is a potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay). It induces GPR35 translocation from the plasma membrane to the cytoplasm with an EC50 value of 22 nM. Pamoic acid also increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a. In vivo, pamoic acid has antinociceptive effects with an ED50 value of 40.5 mg/kg in a mouse abdominal constriction model of visceral pain perception. Pamoate salts, of which pamoic acid is the main constituent, have been used in drug formulations to extend the duration of action.
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