PCNA-I1 |
| Katalog-Nr.GC44577 |
PCNA-I1 ist ein potenter PCNA (Proliferating Cell Nuclear Antigen)-Inhibitor. PCNA-I1 bindet direkt PCNA-Trimere mit einem Kd von 0,41 μM und zeigt sowohl in vitro als auch in vivo AntitumoraktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 444930-42-1
Sample solution is provided at 25 µL, 10mM.
PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 µM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 µM) over non-transformed cells (IC50s = 0.99-2 µM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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