PDD 00017272 |
Katalog-Nr.GC50637 |
PDD 00017272 (34f) ist ein potenter Inhibitor der Poly(ADP-Ribose)-Glycohydrolase (PARG) mit EC50 von 4,8 nM und 9,2 nM im biochemischen Assay bzw. Zell-POM.
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Cas No.: 1945950-20-8
Sample solution is provided at 25 µL, 10mM.
Potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).
Waszkowycz et al (2018) Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 61 10767 PMID:30403352
Average Rating: 5
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