Pelacarsen |
| Katalog-Nr.GC71146 |
Pelacarsen (AKCEA-APO(a)-LRx) ist ein leberspezifisches Antisense-Oligonukleotid gegen Apolipoprotein(a), das Lipoprotein(a) bei guter Verträglichkeit bis zu 80% reduziert.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1637637-70-7
Sample solution is provided at 25 µL, 10mM.
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Mice dosed with Pelacarsen at dose levels of 0.3, 1, 3, and 10 mg/kg once weekly for 6 weeks had dose-dependent reductions in target mRNA expression. The model-estimated doses for Pelacarsen that produced 50% of maximum drug-induced inhibitory effect (ED50) for liver apo(a) mRNA and plasma apo(a) protein levels were 0.32 and 0.54 mg/kg/week, respectively.
References:
[1]. Yu RZ, Graham MJ, Post N, et al. Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice. Mol Ther Nucleic Acids. 2016;5(5):e317.
[2]. Yu RZ, Gunawan R, Post N, et al. Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys. Nucleic Acid Ther. 2016;26(6):372-380.
[3]. Yeang C, et al. Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 Mar 22;79(11):1035-1046.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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