Perospirone |
Katalog-Nr.GC39237 |
Perospiron (freie Base von SM-9018) ist ein oral aktiver Antagonist des 5-HT2A-Rezeptors (Ki = 0,6 nM) und des Dopamin-D2-Rezeptors (Ki = 1,4 nM) und auch ein partieller Agonist des 5-HT1A-Rezeptors (Ki = 2,9 nM). ).
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Cas No.: 150915-41-6
Sample solution is provided at 25 µL, 10mM.
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic drug and has the potential for schizophrenic disease[1][2].
[1]. Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54(4):478-81. [2]. Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18(6):448-54.
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