PF-07238025 |
| Katalog-Nr.GC71322 |
PF-07238025 ist ein BCKDC-Kinase (BDK)-Hemmer (EC50=19 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PF-07238025 (0.2-6 μM; 48 h) reduces pBCKDH in a dose-dependent manner in Hek293 cells, and increases BDK accumulation by 50%[1].
PF-07238025 (20 mg/kg, 100 mg/kg; 8 weeks) reduces glucose excursion after 2 days in HFD-fed mice, and leads significant reduction in both BCAAs and BCKAs by day 7[1].
References:
[1]. Roth Flach RJ, et al. Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels. Nat Commun. 2023 Aug 9;14(1):4812.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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